| http://purl.uniprot.org/citations/11410590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11410590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11410590 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation can both positively and negatively regulate activity of the Raf kinases. Akt has been shown to phosphorylate and inhibit C-Raf activity. We have recently reported that Akt negatively regulates B-Raf kinase activation by phosphorylating multiple residues within its amino-terminal regulatory domain. Here we investigated the regulation of B-Raf by serum and glucocorticoid-inducible kinase, SGK, which shares close sequence identity with the catalytic domain of Akt but lacks the pleckstrin homology domain. We observed that SGK inhibits B-Raf activity. A comparison of substrate specificity between SGK and Akt indicates that SGK is a potent negative regulator of B-Raf. In contrast to Akt, SGK negatively regulates B-Raf kinase activity by phosphorylating only a single Akt consensus site, Ser(364). Under similar experimental conditions, SGK displays a measurably stronger inhibitory effect on B-Raf kinase activity than Akt, whereas Akt exhibits a more inhibitory effect on the forkhead transcription factor, FKHR. The selective substrate specificity is correlated with an enhanced association between Akt or SGK and their preferred substrates, FKHR and B-Raf, respectively. These results indicate that B-Raf kinase activity is negatively regulated by Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102808200"xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102808200"xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Zhu T."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Zhu T."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Greenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Greenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Tang E.D."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Tang E.D."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Vojtek A.B."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Vojtek A.B."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Zhang B.H."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/author | "Zhang B.H."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/pages | "31620-31626"xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/pages | "31620-31626"xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/title | "Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf."xsd:string |
| http://purl.uniprot.org/citations/11410590 | http://purl.uniprot.org/core/title | "Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf."xsd:string |