| http://purl.uniprot.org/citations/11429708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11429708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11429708 | http://www.w3.org/2000/01/rdf-schema#comment | "Hereditary nonpolyposis colorectal cancer (HNPCC) is a common inherited form of neoplasia caused by germline mutations in DNA mismatch repair (MMR) genes. MMR proteins have been reported to associate with several proteins, including the human exonuclease 1 (hEXO1). We report here novel HNPCC-hMLH1 mutant proteins (T117M, Q426X and 1813insA) in Danish HNPCC patients. We demonstrate that these mutant HNPCC-hMLH1 proteins are unable to form complexes with hEXO1 and hPMS2 in vivo. The results indicate that mutations found in HNPCC gene carriers disrupt hMLH1-hEXO1 complex formation and hMutLalpha heterodimer assembly essential for MMR activity."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204467"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204467"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Rasmussen M."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Rasmussen M."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Singh K.K."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Singh K.K."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Bisgaard H.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Bisgaard H.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Rasmussen L.J."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Rasmussen L.J."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Jaeger A.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/author | "Jaeger A.C."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/pages | "3590-3595"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/pages | "3590-3595"xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/title | "HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes."xsd:string |
| http://purl.uniprot.org/citations/11429708 | http://purl.uniprot.org/core/title | "HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes."xsd:string |