| http://purl.uniprot.org/citations/11433299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11433299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11433299 | http://www.w3.org/2000/01/rdf-schema#comment | "The retinoblastoma tumour-suppressor protein (pRb) and p300/CBP co-activator proteins are important for control of proliferation and in tumour cells these are sequestered by viral oncoproteins such as E1A. pRb is involved in negatively regulating growth, and p300/CBP proteins have histone acetyltransferase (HAT) activity, which influences gene expression. Although it is known that phosphorylation by G1 cyclin-dependent kinases (CDKs) regulates pRb activity, the nature and role of other post-translational modifications is not understood. Here we identify acetylation as a new type of modification and level of control in pRb function. Adenovirus E1A, which binds p300/CBP through an amino-terminal transformation-sensitive domain, stimulates the acetylation of pRb by recruiting p300 and pRb into a multimeric-protein complex. Furthermore, pRb acetylation is under cell-cycle control, and acetylation hinders the phosphorylation of pRb by cyclin-dependent kinases. pRb binds more strongly when acetylated to the MDM2 oncoprotein, which indicates that acetylation may regulate protein-protein interactions in the pRb pathway. The acetylation of pRb defines a new level of cell-cycle control mediated by HAT. Furthermore, our results establish a relationship between p300, pRb and acetylation in which E1A acts to recruit and target a cellular HAT activity to pRb."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.org/dc/terms/identifier | "doi:10.1038/35083062"xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.org/dc/terms/identifier | "doi:10.1038/35083062"xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Chan H.M."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Chan H.M."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Demonacos C."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Demonacos C."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Krstic-Demonacos M."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Krstic-Demonacos M."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "La Thangue N.B."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "La Thangue N.B."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Smith L."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/author | "Smith L."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/pages | "667-674"xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/pages | "667-674"xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/title | "Acetylation control of the retinoblastoma tumour-suppressor protein."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/title | "Acetylation control of the retinoblastoma tumour-suppressor protein."xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/11433299 | http://purl.uniprot.org/core/volume | "3"xsd:string |