| http://purl.uniprot.org/citations/11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11440719 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue-specific overexpression of the glycogen synthase kinase-3 (GSK-3) ortholog shaggy (sgg) shortens the period of the Drosophila circadian locomotor activity cycle. The short period phenotype was attributed to premature nuclear translocation of the PERIOD/TIMELESS heterodimer. Reducing SGG/GSK-3 activity lengthens period, demonstrating an intrinsic role for the kinase in circadian rhythmicity. Lowered sgg activity decreased TIMELESS phosphorylation, and it was found that GSK-3 beta specifically phosphorylates TIMELESS in vitro. Overexpression of sgg in vivo converts hypophosphorylated TIMELESS to a hyperphosphorylated protein whose electrophoretic mobility, and light and phosphatase sensitivity, are indistinguishable from the rhythmically produced hyperphosphorylated TIMELESS of wild-type flies. Our results indicate a role for SGG/GSK-3 in TIMELESS phosphorylation and in the regulated nuclear translocation of the PERIOD/TIMELESS heterodimer."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00383-x"xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/author | "Manoukian A.S."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/author | "Young M.W."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/author | "Martinek S."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/author | "Inonog S."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/pages | "769-779"xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/title | "A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock."xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/11440719 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11440719 |
| http://purl.uniprot.org/citations/11440719 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11440719 |
| http://purl.uniprot.org/uniprot/P18431#attribution-09D9FAB1B6B86F181B944A88E983F527 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_A0A1W5PW00-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_A4V3W1-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_A4V3W2-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_A0A9F2GM11-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_C0PUX5-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_A8JUV9-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_P49021-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_M9PGC4-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_M9PGJ3-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |
| http://purl.uniprot.org/uniprot/#_M9PGV7-mappedCitation-11440719 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11440719 |