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| http://purl.uniprot.org/citations/11441186 | http://www.w3.org/2000/01/rdf-schema#comment | "Amyloid-beta precursor protein (APP), a widely expressed cell-surface protein, is cleaved in the transmembrane region by gamma-secretase. gamma-Cleavage of APP produces the extracellular amyloid beta-peptide of Alzheimer's disease and releases an intracellular tail fragment of unknown physiological function. We now demonstrate that the cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1058783"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1058783"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/pages | "115-120"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/pages | "115-120"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/title | "A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/title | "A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60."xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/11441186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11441186 |
| http://purl.uniprot.org/citations/11441186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11441186 |
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| http://purl.uniprot.org/citations/11441186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11441186 |
| http://purl.uniprot.org/uniprot/Q99MK2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11441186 |
| http://purl.uniprot.org/uniprot/P46933#attribution-7B4EE71B40091F356C7FF60C7ADD9719 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11441186 |