| http://purl.uniprot.org/citations/11443112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11443112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11443112 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously cloned and characterized thyroid hormone receptor-binding protein (TRBP) as an LXXLL-containing general coactivator that associates with coactivator complexes through its C terminus. To identify protein cofactors for TRBP action, a Sos-Ras yeast two-hybrid cDNA library was screened using TRBP C terminus as bait. A novel coactivator was isolated, coactivator activator (CoAA), that specifically associates with TRBP. Human CoAA is composed of 669 amino acids with a TRBP-interacting domain and two highly conserved RNA recognition motifs (RRM) commonly found in ribonucleoproteins. A splice variant lacking the entire TRBP-interacting domain was also isolated as a coactivator modulator (CoAM), a 156-amino acid protein containing only the RRM region. Human CoAA and CoAM mRNAs are encoded by a single gene located on chromosome 11q13; alternative splicing in exon 2 of CoAA yields CoAM. CoAA interacts with both TRBP and p300 in vitro. In addition, CoAA potently coactivates transcription mediated by multiple hormone-response elements and acts synergistically with TRBP and CREB-binding protein (CBP). Furthermore, CoAA is associated with the DNA-dependent protein kinase-poly(ADP-ribose) polymerase complex. Strikingly, CoAM, which lacks a TRBP-interacting domain, strongly represses both TRBP and CBP action suggesting that CoAM may modulate endogenous CoAA function. These data suggest that CoAA may serve as a mediator of coactivators such as TRBP in gene activation."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101517200"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101517200"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M101517200"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Iwasaki T."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Iwasaki T."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Chin W.W."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Chin W.W."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Ko L."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/author | "Ko L."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/pages | "33375-33383"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/pages | "33375-33383"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/title | "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/title | "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)."xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11443112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11443112 |
| http://purl.uniprot.org/citations/11443112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11443112 |
| http://purl.uniprot.org/citations/11443112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11443112 |