| http://purl.uniprot.org/citations/11483589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11483589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11483589 | http://www.w3.org/2000/01/rdf-schema#comment | "The DF3/MUC1 mucin-like, transmembrane glycoprotein is aberrantly overexpressed in most human carcinomas. The MUC1 cytoplasmic domain interacts with the c-Src tyrosine kinase and thereby increases binding of MUC1 and beta-catenin. In the present work, coimmunoprecipitation studies demonstrate that MUC1 associates constitutively with the epidermal growth factor receptor (EGF-R) in human ZR-75-1 breast carcinoma cells. Immunofluorescence studies show that EGF-R and MUC1 associate at the cell membrane. We also show that the activated EGF-R phosphorylates the MUC1 cytoplasmic tail on tyrosine at a YEKV motif that functions as a binding site for the c-Src SH2 domain. The results demonstrate that EGF-R-mediated phosphorylation of MUC1 induces binding of MUC1 to c-Src in cells. Moreover, in vitro and in vivo studies demonstrate that EGF-R increases binding of MUC1 and beta-catenin. These findings support a novel role for EGF-R in regulating interactions of MUC1 with c-Src and beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100359200"xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100359200"xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Kuwahara H."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Kuwahara H."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Carraway K.L. III"xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/author | "Carraway K.L. III"xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11483589 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |