| http://purl.uniprot.org/citations/11489994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11489994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11489994 | http://www.w3.org/2000/01/rdf-schema#comment | "Lps-defective C57BL/10ScCr (Cr) mice are homozygous for a deletion encompassing Toll-like receptor 4 that makes them refractory to the biological activity of LPS. In addition, these mice exhibit an inherited IL-12 unresponsiveness resulting in impaired IFN-gamma responses to different microorganisms. By positional cloning methods, we show here that this second defect of Cr mice is due to a mutation in a single gene located on mouse chromosome 6, in close proximity to the Igkappa locus. The gene is IL-12Rbeta2. Cr mice carry a point mutation creating a stop codon that is predicted to cause premature termination of the translated IL-12Rbeta2 after a lysine residue at position 777. The truncated beta2 chain can still form a heterodimeric IL-12R that allows phosphorylation of Janus kinase 2, but, unlike the wild-type IL-12R, can no longer mediate phosphorylation of STAT4. Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence in Cr mice is responsible for their defective IFN-gamma response to microorganisms."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.4.2106"xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.4.2106"xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Nielsen P.J."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Nielsen P.J."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Schupp I."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Schupp I."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Smirnova I."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Smirnova I."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Poltorak A."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Poltorak A."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Galanos C."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Galanos C."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Freudenberg M.A."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Freudenberg M.A."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Merlin T."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Merlin T."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Sandra O."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/author | "Sandra O."xsd:string |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11489994 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |