| http://purl.uniprot.org/citations/11493458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11493458 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11493458 | http://www.w3.org/2000/01/rdf-schema#comment | "It is demonstrated that similar to interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) induces coordinated changes at different steps of the major histocompatibility complex (MHC) class I processing and presentation pathway in nonprofessional antigen-presenting cells (APCs). TNF-alpha up-regulates the expression of 3 catalytic immunoproteasome subunits--LMP2, LMP7, and MECL-1--the immunomodulatory proteasome activator PA28 alpha, the TAP1/TAP2 heterodimer, and the total pool of MHC class I heavy chain. It was also found that in TNF-alpha--treated cells, MHC class I molecules reconstitute more rapidly and have an increased average half-life at the cell surface. Biochemical changes induced by TNF-alpha in the MHC class I pathway were translated into increased sensitivity of TNF-alpha--treated targets to lysis by CD8(+) cytotoxic T cells, demonstrating improved presentation of at least certain endogenously processed MHC class I--restricted peptide epitopes. Significantly, it was demonstrated that the effects of TNF-alpha observed in this experimental system were not mediated through the induction of IFN-gamma. It appears to be likely that TNF-alpha--mediated effects on MHC class I processing and presentation do not involve any intermediate messengers. Collectively, these data demonstrate the existence of yet another biologic activity exerted by TNF-alpha, namely its capacity to act as a coordinated multi-step modulator of the MHC class I pathway of antigen processing and presentation. These results suggest that TNF-alpha may be useful when a concerted up-regulation of the MHC class I presentation machinery is required but cannot be achieved by IFN-gamma. (Blood. 2001;98:1108-1115)"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v98.4.1108"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v98.4.1108"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Levitskaya J."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Levitskaya J."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Seki K."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Seki K."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Castelli C."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Castelli C."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Rivoltini L."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Rivoltini L."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Hallermalm K."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Hallermalm K."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Kiessling R."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/author | "Kiessling R."xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/pages | "1108-1115"xsd:string |
| http://purl.uniprot.org/citations/11493458 | http://purl.uniprot.org/core/pages | "1108-1115"xsd:string |