| http://purl.uniprot.org/citations/11498534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11498534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11498534 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with familial Mediterranean fever suffer sporadic inflammatory attacks characterized by fever and intense pain (in joints, abdomen, or chest). Pyrin, the product of the MEFV locus, is a cytosolic protein whose function is unknown. Using pyrin as a "bait" to probe a yeast two-hybrid library made from neutrophil cDNA, we isolated apoptotic speck protein containing a caspase recruitment domain (CARD) (ASC), a proapoptotic protein that induces the formation of large cytosolic "specks" in transfected cells. We found that when HeLa cells are transfected with ASC, specks are formed. After co-transfection of cells with ASC plus wild type pyrin, an increase in speck-positive cells is found, and speck-positive cells show increased survival. Immunofluorescence studies show that pyrin co-localizes with ASC in specks. Speck localization requires exon 1 of pyrin, but exon 1 alone of pyrin does not result in an increase in the number of specks. Exon 1 of pyrin and exon 1 of ASC show 42% sequence similarity and resemble death domain-related structures in modeling studies. These findings link pyrin to apoptosis pathways and suggest that the modulation of cell survival may be a component of the pathophysiology of familial Mediterranean fever."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m104730200"xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m104730200"xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Diaz A."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Diaz A."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Richards N."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Richards N."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Gumucio D.L."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Gumucio D.L."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Schaner P."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Schaner P."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Shelden E."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Shelden E."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Stuckey J."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Stuckey J."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Wadhwa A."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/author | "Wadhwa A."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/pages | "39320-39329"xsd:string |
| http://purl.uniprot.org/citations/11498534 | http://purl.uniprot.org/core/pages | "39320-39329"xsd:string |