| http://purl.uniprot.org/citations/11514567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11514567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11514567 | http://www.w3.org/2000/01/rdf-schema#comment | "The vitamin D receptor (VDR) is a ligand-dependent transcriptional factor that binds to vitamin D-responsive elements as a heterodimer with retinoid X receptor (RXR) to regulate target gene transcription. The steroid receptor coactivator (SRC) proteins are coactivators that interact with the AF-2 domain of VDR to augment 1,25-dihydroxyvitamin D3-dependent transcription. In contrast, NCoA-62/Ski-interacting protein (SKIP) is a distinct, activation function-2-independent coactivator for VDR. The current study examined whether these two distinct classes of coactivators impact functionally on VDR-mediated transcription. Using a ternary complex binding assay, we observed a marked preference for the direct interaction of NCoA-62/SKIP with the VDR-RXR heterodimer as compared with the VDR-VDR homodimer or VDR monomer. The liganded VDR also formed a ternary complex with NCoA-62/SKIP and SRC proteins in vitro. Competition experiments using LXXLL peptides showed that NCoA-62/SKIP and SRC coactivators contact different domains of the VDR-RXR heterodimer. Synergistic interplays were observed between NCoA-62/SKIP and SRC coactivators in VDR-mediated transcriptional assays, and protein interference assays indicated a requirement for both NCoA-62/SKIP and SRCs in VDR-mediated transcription. These studies suggest that the ligand-dependent and simultaneous interaction of NCoA-62/SKIP and SRC coactivators with distinct interaction domains within the VDR-RXR heterodimer results in cooperative interplays between coactivators in VDR-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106263200"xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m106263200"xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Tokumaru H."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Tokumaru H."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "MacDonald P.N."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "MacDonald P.N."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Dowd D.R."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Dowd D.R."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Baudino T.A."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/author | "Baudino T.A."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/pages | "40614-40620"xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/pages | "40614-40620"xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/title | "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/11514567 | http://purl.uniprot.org/core/title | "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription."xsd:string |