| http://purl.uniprot.org/citations/11524679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11524679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11524679 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathogenesis of transmissible encephalopathies is associated with the conversion of the cellular prion protein, PrP(C), into a conformationally altered oligomeric form, PrP(Sc). Here we report the crystal structure of the human prion protein in dimer form at 2 A resolution. The dimer results from the three-dimensional swapping of the C-terminal helix 3 and rearrangement of the disulfide bond. An interchain two-stranded antiparallel beta-sheet is formed at the dimer interface by residues that are located in helix 2 in the monomeric NMR structures. Familial prion disease mutations map to the regions directly involved in helix swapping. This crystal structure suggests that oligomerization through 3D domain-swapping may constitute an important step on the pathway of the PrP(C) --> PrP(Sc) conversion."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0901-770"xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0901-770"xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Yee V.C."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Yee V.C."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Surewicz W.K."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Surewicz W.K."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Morillas M."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Morillas M."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Malone M."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Malone M."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Swietnicki W."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Swietnicki W."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Knaus K.J."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/author | "Knaus K.J."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/pages | "770-774"xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/pages | "770-774"xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/title | "Crystal structure of the human prion protein reveals a mechanism for oligomerization."xsd:string |
| http://purl.uniprot.org/citations/11524679 | http://purl.uniprot.org/core/title | "Crystal structure of the human prion protein reveals a mechanism for oligomerization."xsd:string |