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http://purl.uniprot.org/citations/11530860http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11530860http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To study the immunolocalization of the Bcl-2 protein in formalin-fixed placental tissue collected from uncomplicated term pregnancies.

Methods

A total of 19 human term placentas of 38-41 weeks' gestation, 11 obtained from spontaneous deliveries and eight from elective caesarean sections prior to labour were included. Sections were incubated with an antibody to the Bcl-2 protein and light microscopy was used to evaluate Bcl-2 staining.

Results

The anti-apoptotic Bcl-2 protein was expressed diffusely throughout the cytoplasm of the syncytiotrophoblast with much less intensive staining in cytotrophoblast and mesenchymal cells. Bcl-2 expression was reduced or lost in areas of syncytial sprouts. No differences in Bcl-2 staining were observed between placentas obtained after spontaneous deliveries and those collected before the onset of labour after elective caesarean section.

Conclusion

Expression of the anti-apoptotic Bcl-2 protein in human term placenta does not seem to be influenced by parturition. Additionally, Bcl-2 expression might be an important factor in the regulation of apoptosis in the human trophoblast and thus in maintaining placental function during gestation."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Schmidt W."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Mink D."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Friedrich M."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Axt-Fliedner R."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Kordina A."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Reitnauer K."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/author"Wasemann C."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/name"Clin Exp Obstet Gynecol"xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/pages"144-147"xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/title"The immunolocalization of Bcl-2 in human term placenta."xsd:string
http://purl.uniprot.org/citations/11530860http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/11530860http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11530860
http://purl.uniprot.org/citations/11530860http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11530860
http://purl.uniprot.org/uniprot/P10415#attribution-7BA7ACD6E1A3DA8CF5ADAC15A7DA10BBhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11530860
http://purl.uniprot.org/uniprot/P10415#attribution-A880125CF2A74D85F08463AC03E2B95Dhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11530860