| http://purl.uniprot.org/citations/11583632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11583632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11583632 | http://www.w3.org/2000/01/rdf-schema#comment | "Sumoylation of p53 by the ubiquitin-like protein, SUMO-1/sentrin/PIC1, has been shown to stimulate its transcriptional activation activity. The SUMO E3 ligase, a key enzyme in the recognition of substrates to be sumoylated, has not yet been identified. We isolated PIAS1 (protein inhibitor of activated STAT1) as a SUMO-1 binding protein by yeast two-hybrid screening. In addition, PIAS1 bound p53 and Ubc9, the E2 for SUMO. PIAS1 that was mutated in the RING finger-like domain bound p53 and SUMO-1, but not Ubc9. PIAS1 catalyzed the sumoylation of p53 both in U2OS cells and in vitro in a domain-dependent manner. These data suggest that PIAS1 functions as a SUMO ligase, or possibly as a tightly bound regulator of it, toward p53."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00349-5"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00349-5"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Yasuda H."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Nishida T."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Nishida T."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Kahyo T."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/author | "Kahyo T."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/pages | "713-718"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/pages | "713-718"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/title | "Involvement of PIAS1 in the sumoylation of tumor suppressor p53."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/title | "Involvement of PIAS1 in the sumoylation of tumor suppressor p53."xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11583632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11583632 |
| http://purl.uniprot.org/citations/11583632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11583632 |
| http://purl.uniprot.org/citations/11583632 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11583632 |
| http://purl.uniprot.org/citations/11583632 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11583632 |