| http://purl.uniprot.org/citations/11585840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11585840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11585840 | http://www.w3.org/2000/01/rdf-schema#comment | "NEDD8 is a ubiquitin-like protein that controls vital biological events through its conjugation to cullin family members. Recently, we identified a negative regulator of the NEDD8 conjugation system, NUB1, which interacts with NEDD8 and down-regulates NEDD8 expression post-transcriptionally (Kito, K., Yeh, E. T. H., and Kamitani, T. (2001) J. Biol. Chem. 276, 20603-20609). Here, we show that NUB1 possesses a ubiquitin-like domain at the N-terminal region and binds to S5a of the 19 S proteasome activator (PA700). A GST pull-down assay revealed that the overexpression of NUB1 leads to a greater precipitation of NEDD8 conjugates with GST-S5a, suggesting that NUB1 might have an adaptor function between S5a and NEDD8. Furthermore, proteasome inhibitors completely block NUB1-mediated down-regulation of NEDD8 expression. These results suggest that NUB1 recruits NEDD8 and its conjugates to the proteasome for degradation, providing a direct functional link between the NEDD8 conjugation system and the proteasomal degradation pathway."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108636200"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m108636200"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Fukuda-Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Fukuda-Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Kamitani T."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Kito K."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Kito K."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/pages | "46655-46660"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/pages | "46655-46660"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/title | "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/title | "Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1."xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11585840 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11585840 |
| http://purl.uniprot.org/citations/11585840 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11585840 |