| http://purl.uniprot.org/citations/11598012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11598012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11598012 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in Bruton's tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. While targeted disruption of the protein kinase C-beta (PKCbeta) gene in mice results in an immunodeficiency similar to xid, the overall tyrosine phosphorylation of Btk is significantly enhanced in PKCbeta-deficient B cells. We provide direct evidence that PKCbeta acts as a feedback loop inhibitor of Btk activation. Inhibition of PKCbeta results in a dramatic increase in B-cell receptor (BCR)-mediated Ca2+ signaling. We identified a highly conserved PKCbeta serine phosphorylation site in a short linker within the Tec homology domain of Btk. Mutation of this phosphorylation site led to enhanced tyrosine phosphorylation and membrane association of Btk, and augmented BCR and FcepsilonRI-mediated signaling in B and mast cells, respectively. These findings provide a novel mechanism whereby reversible translocation of Btk/Tec kinases regulates the threshold for immunoreceptor signaling and thereby modulates lymphocyte activation."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.20.5692"xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.20.5692"xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Chu J."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Chu J."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kawakami T."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kawakami T."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Turck C.W."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Turck C.W."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kang S.W."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kang S.W."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Tarakhovsky A."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Tarakhovsky A."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kitaura J."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kitaura J."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Witte O.N."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Witte O.N."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kato R.M."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Kato R.M."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |
| http://purl.uniprot.org/citations/11598012 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |