http://purl.uniprot.org/citations/11680614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11680614 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11680614 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned a novel member of the tandem pore K+ channel family from human brain cDNA. The novel cDNA encodes a 330-residue polypeptide of predicted molecular mass 36 kDa. We have named the channel TASK-5 owing to its sequence homology with TASK-1 and TASK-3. TASK-5 mRNA is expressed in pancreas, liver, kidney, lung, ovary, testis and heart. However, expression of TASK-5 in heterologous systems failed to elicit ionic currents. Removal of a putative endoplasmic reticulum retention sequence did not alter this finding and the distribution of channel proteins in HEK293 cells was similar for both TASK-1 and TASK-5. We tested whether TASK-5 could form heteromers with TASK-1. We show a mutant form of TASK-1 (H98N) to have a radically reduced sensitivity to acidification. Proton sensitivity could be rescued by injecting equimolar amounts of wild-type and mutant TASK-1 cRNA into Xenopus oocytes; the effect was that expected if half the channels formed are heteromers. Co-expression of TASK-5 with TASK-1 H98N does not affect the proton sensitivity of mutant TASK-1; thus TASK-5 appears not to form heteromers with TASK-1. Nonetheless, TASK-5 may require some other, unidentified partner subunit to form functional channels in the plasma membrane or it may form a channel in an intracellular organelle."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.org/dc/terms/identifier | "doi:10.1007/s004240100620"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.org/dc/terms/identifier | "doi:10.1007/s004240100620"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Ashmole I."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Ashmole I."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Goodwin P.A."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Goodwin P.A."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Stanfield P.R."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/author | "Stanfield P.R."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/name | "Pflugers Arch."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/name | "Pflugers Arch."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/pages | "828-833"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/pages | "828-833"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/title | "TASK-5, a novel member of the tandem pore K+ channel family."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/title | "TASK-5, a novel member of the tandem pore K+ channel family."xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/volume | "442"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://purl.uniprot.org/core/volume | "442"xsd:string |
http://purl.uniprot.org/citations/11680614 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11680614 |
http://purl.uniprot.org/citations/11680614 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11680614 |
http://purl.uniprot.org/citations/11680614 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11680614 |
http://purl.uniprot.org/citations/11680614 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11680614 |