| http://purl.uniprot.org/citations/11689425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11689425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11689425 | http://www.w3.org/2000/01/rdf-schema#comment | "The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a 'free SH2 domain' that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface proteins. Mutations in SH2D1A cause the X-linked lymphoproliferative disease, a primary immunodeficiency. Here we report that a second gene encoding a free SH2 domain, EAT-2, is expressed in macrophages and B lympho cytes. The EAT-2 structure in complex with a phosphotyrosine peptide containing a sequence motif with Tyr281 of the cytoplasmic tail of CD150 is very similar to the structure of SH2D1A complexed with the same peptide. This explains the high affinity of EAT-2 for the pTyr motif in the cytoplasmic tail of CD150 but, unlike SH2D1A, EAT-2 does not bind to non-phosphorylated CD150. EAT-2 binds to the phosphorylated receptors CD84, CD150, CD229 and CD244, and acts as a natural inhibitor, which interferes with the recruitment of the tyrosine phosphatase SHP-2. We conclude that EAT-2 plays a role in controlling signal transduction through at least four receptors expressed on the surface of professional antigen-presenting cells."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.21.5840"xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.21.5840"xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Eck M.J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Eck M.J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Engel P."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Engel P."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Poy F."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Poy F."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Calpe S."xsd:string |
| http://purl.uniprot.org/citations/11689425 | http://purl.uniprot.org/core/author | "Calpe S."xsd:string |