| http://purl.uniprot.org/citations/11698476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11698476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11698476 | http://www.w3.org/2000/01/rdf-schema#comment | "Short-lived peripheral blood eosinophils are recruited to the lungs of asthmatics after allergen challenge, where they become long-lived effector cells central to disease pathophysiology. GM-CSF is an important cytokine which promotes eosinophil differentiation, function, and survival after transit into the lung. In human eosinophils, GM-CSF production is controlled by regulated mRNA stability mediated by the 3' untranslated region, AU-rich elements (ARE). We identified human Y box-binding factor 1 (YB-1) as a GM-CSF mRNA ARE-specific binding protein that is capable of enhancing GM-CSF-dependent survival of eosinophils. Using a transfection system that mimics GM-CSF metabolism in eosinophils, we have shown that transduced YB-1 stabilized GM-CSF mRNA in an ARE-dependent mechanism, causing increased GM-CSF production and enhanced in vitro survival. RNA EMSAs indicate that YB-1 interacts with the GM-CSF mRNA through its 3' untranslated region ARE. In addition, endogenous GM-CSF mRNA coimmunoprecipitates with endogenous YB-1 protein in activated eosinophils but not resting cells. Thus, we propose a model whereby activation of eosinophils leads to YB-1 binding to and stabilization of GM-CSF mRNA, ultimately resulting in GM-CSF release and prolonged eosinophil survival."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.10.5970"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.167.10.5970"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Esnault S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Esnault S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Capowski E.E."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Capowski E.E."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Malter J.S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/author | "Malter J.S."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/pages | "5970-5976"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/pages | "5970-5976"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/title | "Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/title | "Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA."xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/11698476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11698476 |
| http://purl.uniprot.org/citations/11698476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11698476 |