| http://purl.uniprot.org/citations/11700037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11700037 | http://www.w3.org/2000/01/rdf-schema#comment | "CC chemokine receptor 7 (CCR7) expression is crucial for thymocyte trafficking across the corticomedullary junction in the thymus and for lymph node homing of naive T cells. However, the induction mechanism of CCR7 expression is vastly unknown. In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation. Similar changes were induced in a CD4+CD8+CCR7-T cell line upon stimulation with the same combination of reagents, but not with either one alone. These changes were inhibited by U0126, an inhibitor of the extracellular signal-regulated kinase kinase (ERKK/MEK). The transfectants expressing a constitutively active form of the MEK kinase Raf-1 became CD4+CD8+CCR7+ upon stimulation with ionomycin alone. Thus, Raf-1-mediated signals and Ca(2+)-dependent signals are essential to induce CCR7 expression in CD4+CD8+ T cells and thymocytes as well as their differentiation."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.5912"xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/author | "Adachi S."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/author | "Iwata M."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/author | "Kuwata T."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/author | "Miyaike M."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/pages | "1188-1193"xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/title | "Induction of CCR7 expression in thymocytes requires both ERK signal and Ca(2+) signal."xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/11700037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11700037 |
| http://purl.uniprot.org/citations/11700037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11700037 |
| http://purl.uniprot.org/uniprot/P47774#attribution-B046FB8D435257082A7B556BE463E5F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11700037 |
| http://purl.uniprot.org/uniprot/#_P47774-mappedCitation-11700037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11700037 |
| http://purl.uniprot.org/uniprot/#_Q3U3J0-mappedCitation-11700037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11700037 |
| http://purl.uniprot.org/uniprot/P47774 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11700037 |
| http://purl.uniprot.org/uniprot/Q3U3J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11700037 |