| http://purl.uniprot.org/citations/11719186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11719186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11719186 | http://www.w3.org/2000/01/rdf-schema#comment | "Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3' untranslated regions. Although found 15 years ago, the mechanism by which AREs dictate rapid mRNA decay is not clear. In yeast, 3'-to-5' mRNA degradation is mediated by the exosome, a multisubunit particle. We have purified and characterized the human exosome by mass spectrometry and found its composition to be similar to its yeast counterpart. Using a cell-free RNA decay system, we demonstrate that the mammalian exosome is required for rapid degradation of ARE-containing RNAs but not for poly(A) shortening. The mammalian exosome does not recognize ARE-containing RNAs on its own. ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00578-5"xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00578-5"xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Chen C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Chen C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Gherzi R."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Gherzi R."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Moroni C."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Moroni C."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Raijmakers R."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Pruijn G.J.M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Pruijn G.J.M."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Ong S.-E."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Ong S.-E."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Chan E.L."xsd:string |
| http://purl.uniprot.org/citations/11719186 | http://purl.uniprot.org/core/author | "Chan E.L."xsd:string |