| http://purl.uniprot.org/citations/11756546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11756546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11756546 | http://www.w3.org/2000/01/rdf-schema#comment | "Autonomously replicating sequence-binding factor 1 (ABF1) is a multifunctional, site-specific DNA binding protein that is essential for cell viability in Saccharomyces cerevisiae. ABF1 plays a direct role in transcriptional activation, stimulation of DNA replication, and gene silencing at the mating-type loci. Here we demonstrate that all three activities of ABF1 are conferred by the C terminus of the protein (amino acids [aa] 604 to 731). Furthermore, a detailed mutational analysis has revealed two important clusters of amino acid residues in the C terminus (C-terminal sequence 1 [CS1], aa 624 to 628; and CS2, aa 639 to 662). While both regions play a pivotal role in supporting cell viability, they make distinct contributions to ABF1 functions in various nuclear processes. CS1 specifically participates in transcriptional silencing and/or repression in a context-dependent manner, whereas CS2 is universally required for all three functions of ABF1. When tethered to specific regions of the genome, a 30-aa fragment that contains CS2 alone is sufficient for activation of transcription and chromosomal replication. In addition, CS2 is responsible for ABF1-mediated chromatin remodeling. Based on these results, we suggest that ABF1 may function as a chromatin-reorganizing factor to increase accessibility of the local chromatin structure, which in turn facilitates the action of additional factors to establish either an active or repressed chromatin state."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.2.505-516.2002"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.2.505-516.2002"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Loch C.M."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Loch C.M."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Miyake T."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/author | "Miyake T."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/pages | "505-516"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/pages | "505-516"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/title | "Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/title | "Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing."xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/11756546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11756546 |
| http://purl.uniprot.org/citations/11756546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11756546 |
| http://purl.uniprot.org/citations/11756546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11756546 |
| http://purl.uniprot.org/citations/11756546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11756546 |