| http://purl.uniprot.org/citations/11784859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11784859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11784859 | http://www.w3.org/2000/01/rdf-schema#comment | "Sin3 is an evolutionarily conserved corepressor that exists in different complexes with the histone deacetylases HDAC1 and HDAC2. Sin3-HDAC complexes are believed to deacetylate nucleosomes in the vicinity of Sin3-regulated promoters, resulting in a repressed chromatin structure. We have previously found that a human Sin3-HDAC complex includes HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, and two novel polypeptides SAP30 and SAP18. SAP30 is a specific component of Sin3 complexes since it is absent in other HDAC1/2-containing complexes such as NuRD. SAP30 mediates interactions with different polypeptides providing specificity to Sin3 complexes. We have identified p33ING1b, a negative growth regulator involved in the p53 pathway, as a SAP30-associated protein. Two distinct Sin3-p33ING1b-containing complexes were isolated, one of which associates with the subunits of the Brg1-based Swi/Snf chromatin remodeling complex. The N terminus of p33ING1b, which is divergent among a family of ING1 polypeptides, associates with the Sin3 complex through direct interaction with SAP30. The N-terminal domain of p33 is present in several uncharacterized human proteins. We show that overexpression of p33ING1b suppresses cell growth in a manner dependent on the intact Sin3-HDAC-interacting domain."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.3.835-848.2002"xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.3.835-848.2002"xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Erdjument-Bromage H."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Kuzmichev A."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/author | "Kuzmichev A."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/pages | "835-848"xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/pages | "835-848"xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/title | "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/title | "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)."xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/11784859 | http://purl.uniprot.org/core/volume | "22"xsd:string |