| http://purl.uniprot.org/citations/11788823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11788823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11788823 | http://www.w3.org/2000/01/rdf-schema#comment | "The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin (hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/San), we observed abnormally low plasma lipid levels (hypolipidemia). This mutant phenotype is inherited recessively as a mendelian trait. Here we report the mapping of the hypolipidemia (hypl) locus to the middle of chromosome 4 and positional cloning of the autosomal recessive mutation responsible for the hypolipidemia. The hypl locus encodes a unique angiopoietin-like lipoprotein modulator, which we named Allm1. It is identical to angiopoietin-like protein 3, encoded by Angptl3, and has a highly conserved counterpart in humans. Overexpression of Angptl3 or intravenous injection of the purified protein in KK/San mice elicited an increase in circulating plasma lipid levels. This increase was also observed in C57BL/6J normal mice. Taken together, these data suggest that Angptl3 regulates lipid metabolism in animals."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng814"xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng814"xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Fujiwara T."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Fujiwara T."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Ono M."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Ando Y."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Ando Y."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Shimamura M."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Shimamura M."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Furukawa H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Furukawa H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Horikoshi H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Horikoshi H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Koishi R."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Koishi R."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Yasumo H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/author | "Yasumo H."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/11788823 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |