| http://purl.uniprot.org/citations/11823861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11823861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11823861 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of naive CD4(+) T-helper cells results in the development of at least two distinct effector populations, Th1 and Th2 cells. Th1 cells produce cytokines (interferon (IFN)-gamma, interleukin (IL)-2, tumour-necrosis factor (TNF)-alpha and lymphotoxin) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. Th2 cells produce cytokines (IL-4, IL-10 and IL-13) that are crucial for control of extracellular helminthic infections and promote atopic and allergic diseases. Although much is known about the functions of these two subsets of T-helper cells, there are few known surface molecules that distinguish between them. We report here the identification and characterization of a transmembrane protein, Tim-3, which contains an immunoglobulin and a mucin-like domain and is expressed on differentiated Th1 cells. In vivo administration of antibody to Tim-3 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and increases the number and activation level of macrophages. Tim-3 may have an important role in the induction of autoimmune diseases by regulating macrophage activation and/or function."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.org/dc/terms/identifier | "doi:10.1038/415536a"xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.org/dc/terms/identifier | "doi:10.1038/415536a"xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Manning S."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Manning S."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Freeman G.J."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Sabatos C.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Sabatos C.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Chernova T."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Chernova T."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Greenfield E.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Greenfield E.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Sobel R.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Sobel R.A."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Gaglia J.L."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Gaglia J.L."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Monney L."xsd:string |
| http://purl.uniprot.org/citations/11823861 | http://purl.uniprot.org/core/author | "Monney L."xsd:string |