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http://purl.uniprot.org/citations/11860508http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11860508http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11860508http://www.w3.org/2000/01/rdf-schema#comment"The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains. Here we describe a new protein, CGI-94, that is down-regulated at the mRNA level in the hippocampus of early stage AD brain. Transfection experiments with CGI-94 as a green fluorescent protein (GFP)-fusion-protein show that this protein is translocated into the nucleus of the cell. The finding that this protein, which has a bipartite nuclear localization signal, is also observed in the cytoplasm and extracellular space points to a multifunctional protein. Immunohistochemical analyses reveal that CGI-94 is mainly expressed in neurons of the hippocampal formation and the cortex but not in the cerebellar nucleus. In conclusion, the expression of the nucleolar phosphoprotein CGI-94 appears to be disturbed in early processes of neuronal degeneration."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.org/dc/terms/identifier"doi:10.1046/j.0953-816x.2001.01836.x"xsd:string
http://purl.uniprot.org/citations/11860508http://purl.org/dc/terms/identifier"doi:10.1046/j.0953-816x.2001.01836.x"xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Nagai Y."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Nagai Y."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Nakayama T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Nakayama T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Yamamoto T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Yamamoto T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Kosaka K."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Kosaka K."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Heese K."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Heese K."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Sawada T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Sawada T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Akatsu H."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Akatsu H."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Hata R."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Hata R."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Suemoto T."xsd:string
http://purl.uniprot.org/citations/11860508http://purl.uniprot.org/core/author"Suemoto T."xsd:string