| http://purl.uniprot.org/citations/11864910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11864910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11864910 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously shown that the hematopoietic Ets transcription factor PU.1 interacts with the transcriptional coactivator CREB-binding protein (CBP). In this study, we further investigated whether Spi-B, another hematopoietic Ets transcription factor, also interacts with CBP. Direct physical interaction of Spi-B with CBP was demonstrated by glutathione S-transferase binding assay. Analysis using several deletion mutants of Spi-B and CBP revealed that the NH2-terminal region including the activation domain of Spi-B interacted with the region spanning amino acid residues 1283-1915 of CBP in vitro. The interaction of Spi-B with CBP was also observed in vivo. CBP potentiated Spi-B-mediated transcription of the reporter gene driven by the multimerized PU.1/Spi-B binding sites. This transcriptional activation by Spi-B and CBP was inhibited by expression of c-Myb, and the transcriptional activation by c-Myb and CBP was inhibited by expression of Spi-B, suggesting competition for CBP between these two transcription factors. Our results suggest that CBP acts as a transcriptional coactivator of Spi-B and mediates synergistic or antagonistic interactions between other transcription factors."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Oikawa T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Oikawa T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Kihara-Negishi F."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/author | "Kihara-Negishi F."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/name | "Cell Growth Differ."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/name | "Cell Growth Differ."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/pages | "69-75"xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/pages | "69-75"xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/title | "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/title | "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb."xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/11864910 | http://purl.uniprot.org/core/volume | "13"xsd:string |