| http://purl.uniprot.org/citations/11867758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11867758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11867758 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines regulate lymphocyte development and differentiation, but precisely how they control these processes is still poorly understood. By using microarray technology to detect cytokine-induced genes, we identified a cDNA encoding Cybr, which was increased markedly in cells incubated with IL-2 and IL-12. The mRNA was most abundant in hematopoietic cells and tissues. The predicted amino acid sequence is similar to that of GRP-1-associated protein (GRASP), a recently identified retinoic acid-induced cytohesin-binding protein. Physical interaction, dependent on the coiled-coil domains of Cybr and cytohesin-1, was demonstrated by coimmunoprecipitation of the overexpressed proteins from 293T cells. Cytohesin-1, in addition to its role in cell adhesion, is a guanine nucleotide-exchange protein activator of ARF GTPases. Acceleration of guanosine 5prime prime or minute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr. Because the binding protein modified activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytohesin binder and regulator)."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.052712999"xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.052712999"xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Tang P."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Tang P."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Moss J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Moss J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Vaughan M."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Vaughan M."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Gadina M."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Gadina M."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Wu C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Wu C.-Y."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Cheng T.P."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Cheng T.P."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Agnello D."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Agnello D."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Ahn H.-J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Ahn H.-J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Galon J."xsd:string |
| http://purl.uniprot.org/citations/11867758 | http://purl.uniprot.org/core/author | "Galon J."xsd:string |