| http://purl.uniprot.org/citations/11877415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11877415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11877415 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor beta (TGFbeta) receptors require SARA for phosphorylation of the downstream transducing Smad proteins. SARA, a FYVE finger protein, binds to membrane lipids suggesting that activated receptors may interact with downstream signaling molecules at discrete endocytic locations. In the present study, we reveal a critical role for the early endocytic compartment in regulating Smad-dependent signaling. Not only is SARA localized on early endosomes, but also its minimal FYVE finger sequence is sufficient for early endosomal targeting. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. Moreover, a dominant-negative mutant of Rab5, a crucial protein for early endosome dynamics, causes phosphorylation and nuclear translocation of Smads leading to constitutive (i.e. ligand independent) transcriptional activation of a Smad-dependent promoter in endothelial cells. As inhibition of endocytosis using the K44A negative mutant of dynamin and RN-tre did not lead to activation of Smad-dependent transcription, the effects of the dominant-negative Rab5 are likely to be a consequence of altered membrane trafficking of constitutively formed TGFbeta/activin type I/II receptor complexes at the level of early endosomes. The results suggest an important interconnection between early endosomal dynamics and TGFbeta/activin signal transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m107983200"xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m107983200"xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Murphy C."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Murphy C."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Fotsis T."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Fotsis T."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Gillooly D.J."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Gillooly D.J."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Panopoulou E."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/author | "Panopoulou E."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/pages | "18046-18052"xsd:string |
| http://purl.uniprot.org/citations/11877415 | http://purl.uniprot.org/core/pages | "18046-18052"xsd:string |