| http://purl.uniprot.org/citations/11907034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11907034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11907034 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein-tyrosine phosphatase 1B (PTP1B) has recently received much attention as a potential drug target in type 2 diabetes. This has in particular been spurred by the finding that PTP1B knockout mice show increased insulin sensitivity and resistance to diet-induced obesity. Surprisingly, the highly homologous T cell protein-tyrosine phosphatase (TC-PTP) has received much less attention, and no x-ray structure has been provided. We have previously co-crystallized PTP1B with a number of low molecular weight inhibitors that inhibit TC-PTP with similar efficiency. Unexpectedly, we were not able to co-crystallize TC-PTP with the same set of inhibitors. This seems to be due to a multimerization process where residues 130-132, the DDQ loop, from one molecule is inserted into the active site of the neighboring molecule, resulting in a continuous string of interacting TC-PTP molecules. Importantly, despite the high degree of functional and structural similarity between TC-PTP and PTP1B, we have been able to identify areas close to the active site that might be addressed to develop selective inhibitors of each enzyme."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200567200"xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200567200"xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Mortensen S.B."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Mortensen S.B."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Pedersen A.K."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Pedersen A.K."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Iversen L.F."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Iversen L.F."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Peters G.H."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Peters G.H."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Branner S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Branner S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Petersen A.S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Petersen A.S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Andersen H.S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Andersen H.S."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Moller K.B."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Moller K.B."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Moller N.P."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/author | "Moller N.P."xsd:string |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11907034 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |