| http://purl.uniprot.org/citations/11927608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11927608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11927608 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane-associated guanylate kinase (Maguk) proteins are scaffold proteins that contain PSD-95-Discs Large-zona occludens-1 (PDZ), Src homology 3, and guanylate kinase domains. A subset of Maguk proteins, such as mLin-2 and protein associated with Lin-7 (Pals)1, also contain two L27 domains: an L27C domain that binds mLin-7 and an L27N domain of unknown function. Here, we demonstrate that the L27N domain targets Pals1 to tight junctions by binding to a PDZ domain protein, Pals1-associated tight junction (PATJ) protein, via a unique Maguk recruitment domain. PATJ is a homologue of Drosophila Discs Lost, a protein that is crucial for epithelial polarity and that exists in a complex with the apical polarity determinant, Crumbs. PATJ and a human Crumbs homologue, CRB1, colocalize with Pals1 to tight junctions, and CRB1 interacts with PATJ albeit indirectly via binding the Pals1 PDZ domain. In agreement, we find that a Drosophila homologue of Pals1 participates in identical interactions with Drosophila Crumbs and Discs Lost. This Drosophila Pals1 homologue has been demonstrated recently to represent Stardust, a crucial polarity gene in Drosophila. Thus, our data identifies a new multiprotein complex that appears to be evolutionarily conserved and likely plays an important role in protein targeting and cell polarity."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200109010"xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200109010"xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Goyal M."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Goyal M."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Liu C.-J."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Liu C.-J."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Wiggins R."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Wiggins R."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Shin K."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Shin K."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Makarova O."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Makarova O."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Laurinec S."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Laurinec S."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Roh M.H."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/author | "Roh M.H."xsd:string |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11927608 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |