| http://purl.uniprot.org/citations/11940666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11940666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11940666 | http://www.w3.org/2000/01/rdf-schema#comment | "CLIP-170 is a plus-end tracking protein which may act as an anticatastrophe factor. It has been proposed to mediate the association of dynein/dynactin to microtubule (MT) plus ends, and it also binds to kinetochores in a dynein/dynactin-dependent fashion, both via its C-terminal domain. This domain contains two zinc finger motifs (proximal and distal), which are hypothesized to mediate protein-protein interactions. LIS1, a protein implicated in brain development, acts in several processes mediated by the dynein/dynactin pathway by interacting with dynein and other proteins. Here we demonstrate colocalization and direct interaction between CLIP-170 and LIS1. In mammalian cells, LIS1 recruitment to kinetochores is dynein/dynactin dependent, and recruitment there of CLIP-170 is dependent on its site of binding to LIS1, located in the distal zinc finger motif. Overexpression of CLIP-170 results in a zinc finger-dependent localization of a phospho-LIS1 isoform and dynactin to MT bundles, raising the possibility that CLIP-170 and LIS1 regulate dynein/dynactin binding to MTs. This work suggests that LIS1 is a regulated adapter between CLIP-170 and cytoplasmic dynein at sites involved in cargo-MT loading, and/or in the control of MT dynamics."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.9.3089-3102.2002"xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.9.3089-3102.2002"xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Hoogenraad C.C."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Hoogenraad C.C."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Galjart N."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Galjart N."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Dompierre J.P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Dompierre J.P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Reiner O."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Reiner O."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Coquelle F.M."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Coquelle F.M."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Cordelieres F.P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Cordelieres F.P."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Caspi M."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "Caspi M."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "De Mey J.R."xsd:string |
| http://purl.uniprot.org/citations/11940666 | http://purl.uniprot.org/core/author | "De Mey J.R."xsd:string |