| http://purl.uniprot.org/citations/11961546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11961546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11961546 | http://www.w3.org/2000/01/rdf-schema#comment | "SCF complexes are the largest family of E3 ubiquitin-protein ligases and mediate the ubiquitination of diverse regulatory and signalling proteins. Here we present the crystal structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF complex, which shows that Cul1 is an elongated protein that consists of a long stalk and a globular domain. The globular domain binds the RING finger protein Rbx1 through an intermolecular beta-sheet, forming a two-subunit catalytic core that recruits the ubiquitin-conjugating enzyme. The long stalk, which consists of three repeats of a novel five-helix motif, binds the Skp1-F boxSkp2 protein substrate-recognition complex at its tip. Cul1 serves as a rigid scaffold that organizes the Skp1-F boxSkp2 and Rbx1 subunits, holding them over 100 A apart. The structure suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.org/dc/terms/identifier | "doi:10.1038/416703a"xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.org/dc/terms/identifier | "doi:10.1038/416703a"xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Chu C."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Chu C."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Jeffrey P.D."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Pavletich N.P."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Schulman B.A."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Schulman B.A."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/11961546 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |