| http://purl.uniprot.org/citations/11964389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11964389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11964389 | http://www.w3.org/2000/01/rdf-schema#comment | "dCrumbs is an apical organizer crucial for the maintenance of epithelial polarity in Drosophila (1). It is known that dCrumbs interacts with Discs lost (Dlt), a protein with four PDZ (PSD95/Discs Large/ZO-1) domains (2), and Stardust (Sdt), a protein of the MAGUK (membrane-associated guanylate kinase) family (3, 4). We have searched for potential homologs of Dlt in human epithelial cells and characterized one of them in intestinal epithelial cells. Human INAD-like (hINADl) contains 8 PDZ domains, is concentrated in tight junctions, and is also found at the apical plasma membrane. Overexpression of hINADl disrupted the tight junctions localization of ZO-1 and 3. We also identified a partial cDNA coding the transmembrane and cytoplasmic domains of a new human crumbs (CRB3) expressed in Caco-2 cells. This CRB3 was able to interact through its C-terminal end with the N-terminal domain of hINADl. Taken together, the data indicate that hINADl is likely to represent a Dlt homolog in mammalian epithelial cells and might be involved in regulating the integrity of tight junctions. We thus propose to rename hINADl PATJ for protein associated to tight junctions."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202196200"xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202196200"xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Medina E."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Medina E."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Michel D."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Michel D."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Le Bivic A."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Le Bivic A."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Arsanto J.-P."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Arsanto J.-P."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Delgrossi M.-H."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Delgrossi M.-H."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Lemmers C."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/author | "Lemmers C."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/pages | "25408-25415"xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/pages | "25408-25415"xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/title | "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/11964389 | http://purl.uniprot.org/core/title | "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells."xsd:string |