| http://purl.uniprot.org/citations/11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11967989 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) and interleukin-4 (IL-4) have fibrogenic properties and induce extracellular matrix production in a variety of lung diseases. Connective tissue growth factor (CTGF) is a matrix signaling molecule stimulated by TGF-beta that in part mediates alpha1(I) collagen mRNA expression. In these studies, the regulation of CTGF expression by IL-4 in human lung fibroblasts was examined. Following 6 h of stimulation with IL-4, basal CTGF mRNA levels were unchanged as assessed by Northern blot analysis. However, IL-4 attenuated the TGF-beta-stimulated induction of CTGF mRNA expression by 50%. This effect was selective because IL-4 did not affect fibronectin or alpha1(I) collagen mRNA expression induced by TGF-beta. Experiments employing the transcriptional inhibitor actinomycin D suggest that IL-4 did not affect the stability of the CTGF mRNA. Transient transfection assays with 3TP-Lux, a luciferase gene controlled by a TGF-beta inducible promoter, and with a CTGF promoter construct indicate that IL-4 interfered with the TGF-beta-induced transcriptional activation of the CTGF gene."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.10144"xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/author | "Goldstein R.H."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/author | "Ricupero D.A."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/author | "Kuang P.P."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/author | "Rishikof D.C."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/pages | "496-504"xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/title | "Interleukin-4 regulates connective tissue growth factor expression in human lung fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/11967989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11967989 |
| http://purl.uniprot.org/citations/11967989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11967989 |
| http://purl.uniprot.org/uniprot/P05112#attribution-9E94023DDD5BC598349668B1445A4E89 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_D4HNR6-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_B2RCP7-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_B3KRV6-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_A1Z2K1-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_B0JFA2-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_B3KWK5-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_G8Z3H3-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_P05112-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |
| http://purl.uniprot.org/uniprot/#_P29279-mappedCitation-11967989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11967989 |