| http://purl.uniprot.org/citations/11980906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11980906 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the cDNA cloning and functional characterization of human cyclin L, a novel cyclin related to the C-type cyclins that are involved in regulation of RNA polymerase II (pol II) transcription. Cyclin L also contains a COOH-terminal dipeptide repeat of alternating arginines and serines, a hallmark of the SR family of splicing factors. We show that recombinant cyclin L interacts with p110 PITSLRE kinase, and that cyclin L antibody co-immunoprecipitates a kinase activity from HeLa nuclear extracts that phosphorylates the carboxyl-terminal domain (CTD) of pol II and splicing factor SC35, and is inhibited by the cdk inhibitor p21. Cyclin L antibody inhibits the second step of RNA splicing in vitro, and recombinant cyclin L protein stimulates splicing under suboptimal conditions. Significantly, the IC(50) for splicing inhibition by p21 is similar to the IC(50) for inhibition of the cyclin L-associated kinase activity. Cyclin L and its associated kinase are thus new members of the pre-mRNA processing machinery."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202266200"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202266200"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Edgar A.J."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Edgar A.J."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Dickinson L.A."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Dickinson L.A."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Ehley J."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Ehley J."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Gottesfeld J.M."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/author | "Gottesfeld J.M."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/pages | "25465-25473"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/pages | "25465-25473"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/title | "Cyclin L is an RS domain protein involved in pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/title | "Cyclin L is an RS domain protein involved in pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/11980906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11980906 |
| http://purl.uniprot.org/citations/11980906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11980906 |