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| http://purl.uniprot.org/citations/12015964 | http://www.w3.org/2000/01/rdf-schema#comment | "Rho GTPases regulate several aspects of tissue morphogenesis during animal development. We found that mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor. In p190-B RhoGAP-deficient mice, CREB phosphorylation is substantially reduced in embryonic tissues. Embryo-derived cells contain abnormally high levels of active Rho protein, are reduced in size, and exhibit defects in CREB activation upon exposure to insulin or IGF-1. The cell size defect is rescued by expression of constitutively activated CREB, and in wild-type cells, expression of activated Rho or dominant-negative CREB results in reduced cell size. Together, these results suggest that activity of the Rho GTPase modulates a signal from insulin/IGFs to CREB that determines cell size and animal size during embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00162-4"xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Takami H."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Settleman J."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Hu K.Q."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Classon M."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Sordella R."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Fine B."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Brouns M.R."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/author | "Matheson S.F."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/pages | "553-565"xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/title | "Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development."xsd:string |
| http://purl.uniprot.org/citations/12015964 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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