| http://purl.uniprot.org/citations/12016314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12016314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12016314 | http://www.w3.org/2000/01/rdf-schema#comment | "The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We show that VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. VDR is an order of magnitude more sensitive to LCA and its metabolites than are other nuclear receptors. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1070477"xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1070477"xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Xie W."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Xie W."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Domoto H."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Domoto H."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Makishima M."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Makishima M."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Haussler M.R."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Haussler M.R."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Lu T.T."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Lu T.T."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Whitfield G.K."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/author | "Whitfield G.K."xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12016314 | http://purl.uniprot.org/core/name | "Science"xsd:string |