| http://purl.uniprot.org/citations/12050112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12050112 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of gene transcription in mammalian cells requires several classes of coactivators that participate in different steps of the activation cascade. Using conventional and affinity chromatography, we have isolated a human coactivator complex that interacts directly with the C-terminal domain (CTD) of RNA polymerase II (Pol II). The CTD-binding complex is structurally and functionally indistinguishable from our previously isolated CRSP coactivator complex. The closely related, but transcriptionally inactive, ARC-L complex failed to interact with the CTD, indicating a significant biochemical difference between CRSP and ARC-L that may, in part, explain their functional divergence. Electron microscopy and three-dimensional single-particle reconstruction reveals a conformation for CTD-CRSP that is structurally distinct from unliganded CRSP or CRSP bound to SREBP-1a, but highly similar to CRSP bound to the VP16 activator. Together, our findings suggest that the human CRSP coactivator functions, at least in part, by mediating activator-dependent recruitment of RNA Pol II via the CTD."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.987602"xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/author | "Tjian R."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/author | "Zhai W."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/author | "Taatjes D.J."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/author | "Naar A.M."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/pages | "1339-1344"xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/title | "Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation."xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12050112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12050112 |
| http://purl.uniprot.org/citations/12050112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12050112 |
| http://purl.uniprot.org/uniprot/#_B4DH29-mappedCitation-12050112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12050112 |
| http://purl.uniprot.org/uniprot/#_B2WTN6-mappedCitation-12050112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12050112 |
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| http://purl.uniprot.org/uniprot/#_O95402-mappedCitation-12050112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12050112 |
| http://purl.uniprot.org/uniprot/#_P30876-mappedCitation-12050112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12050112 |
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| http://purl.uniprot.org/uniprot/B4DHJ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12050112 |