| http://purl.uniprot.org/citations/12072434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12072434 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12072434 | http://www.w3.org/2000/01/rdf-schema#comment | "The members of the AP-2 family of transcription factors are developmentally regulated and have distinct yet overlapping functions in the regulation of many genes governing growth and differentiation. All AP-2 factors appear to be capable of binding very similar DNA recognition sites, and the determinants of functional specificity remain to be elucidated. AP-2 transcription factors have been shown to act both as transcriptional activators and repressors in a promoter-specific manner. Although several mediators of their activation function have been suggested, few mechanisms for the repression or down-regulation of transactivation have been described. In a two-hybrid screen for proteins interacting with AP-2 factors, we have identified the UBC9 gene that encodes the E2 (ubiquitin carrier protein)-conjugating enzyme for the small ubiquitin-like modifier, SUMO. The interaction domain resides in the C-terminal half of AP-2, which contains the conserved DNA binding and dimerization domains. We have detected sumolated forms of endogenous AP-2 in mammalian cells and have further mapped the in vivo sumolation site to conserved lysine 10. Transient transfection studies indicate that sumolation of AP-2 decreases its transcription activation potential, and we discuss the possible mechanisms for the observed suppression of AP-2 transactivation."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202780200"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m202780200"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/author | "Eloranta J.J."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/author | "Eloranta J.J."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/author | "Hurst H.C."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/author | "Hurst H.C."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/pages | "30798-30804"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/pages | "30798-30804"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/title | "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/title | "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo."xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12072434 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12072434 |
| http://purl.uniprot.org/citations/12072434 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12072434 |
| http://purl.uniprot.org/citations/12072434 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12072434 |
| http://purl.uniprot.org/citations/12072434 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12072434 |
| http://purl.uniprot.org/uniprot/Q92481 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12072434 |
| http://purl.uniprot.org/uniprot/Q92754 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12072434 |