| http://purl.uniprot.org/citations/12087103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12087103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12087103 | http://www.w3.org/2000/01/rdf-schema#comment | "p21(SNFT) (21-kDa small nuclear factor isolated from T cells) is a novel human protein of the basic leucine zipper family. The overexpression of p21(SNFT) leads to the significant and specific repression of transcription from the interleukin-2 promoter as well as from several essential activator protein 1 (AP-1)-driven composite promoter elements. One example is the distal nuclear factor of activated T cells (NF-AT)/AP-1 element where the AP-1 (Fos/Jun) basic leucine zipper heterodimer interacts with members of the NF-AT family. p21(SNFT) has been shown to replace Fos in dimerization with Jun on a consensus AP-1 binding site (12-O-tetradecanolyphorbol-13-acetate response element (TRE)) and to interact with Jun and NF-AT at the distal NF-AT/AP-1 enhancer element. A detailed biochemical analysis presented here compares interactions involving p21(SNFT) with those involving Fos. The results demonstrate that a p21(SNFT)/Jun dimer binds a TRE similarly to AP-1 and like AP-1 binds cooperatively with NF-AT at the NF-AT/AP-1 composite element. However, Fos interacts significantly more efficiently than p21(SNFT) with Jun and NF-AT, and the replacement of Fos by p21(SNFT) in the trimolecular complex drastically alters protein-DNA contacts. The data suggest that p21(SNFT) may repress transcriptional activity by inducing a unique conformation in the transcription factor complex."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205048200"xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205048200"xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Wachsman W."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Wachsman W."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Bower K.E."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Bower K.E."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Martinez T."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Martinez T."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "McGuire K.L."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "McGuire K.L."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Zeller R.W."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/author | "Zeller R.W."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/pages | "34967-34977"xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/pages | "34967-34977"xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/title | "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/title | "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12087103 | http://purl.uniprot.org/core/volume | "277"xsd:string |