| http://purl.uniprot.org/citations/12093754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093754 | http://www.w3.org/2000/01/rdf-schema#comment | "Newly spliced mRNAs in mammalian cells are characterized by a complex of proteins at exon-exon junctions. This complex recruits Upf3 and Upf2, which function in nonsense-mediated mRNA decay (NMD). Both Upf proteins are detected on mRNA bound by the major nuclear cap-binding proteins CBP80/CBP20 but not mRNA bound by the major cytoplasmic cap-binding protein eIF4E. These and other data indicate that NMD targets CBP80-bound mRNA during a 'pioneer' round of translation, but whether nuclear eIF4E also binds nascent but dead-end transcripts is unclear. Here we provide evidence that nuclear CBP80 but not nuclear eIF4E is readily detected in association with intron-containing RNA and the C-terminal domain of RNA polymerase II. Consistent with this evidence, we demonstrate that RNPS1, Y14, SRm160, REF/Aly, TAP, Upf3X and Upf2 are detected in the nuclear fraction on CBP80-bound but not eIF4E-bound mRNA. Each of these proteins is also detected on CBP80-bound mRNA in the cytoplasmic fraction, indicating a presence on mRNA after export. The dynamics of mRNP composition before and after mRNA export are discussed."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf345"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf345"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Ishigaki Y."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Ishigaki Y."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Lejeune F."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/author | "Lejeune F."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/pages | "3536-3545"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/pages | "3536-3545"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/title | "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/title | "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling."xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12093754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093754 |
| http://purl.uniprot.org/citations/12093754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093754 |