| http://purl.uniprot.org/citations/12110186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110186 | http://www.w3.org/2000/01/rdf-schema#comment | "How membrane receptors initiate signal transduction upon ligand binding is a matter of intense scrutiny. The T cell receptor complex (TCR-CD3) is composed of TCR alpha/beta ligand binding subunits bound to the CD3 subunits responsible for signal transduction. Although it has long been speculated that TCR-CD3 may undergo a conformational change, confirmation is still lacking. We present strong evidence that ligand engagement of TCR-CD3 induces a conformational change that exposes a proline-rich sequence in CD3 epsilon and results in recruitment of the adaptor protein Nck. This occurs earlier than and independently of tyrosine kinase activation. Finally, by interfering with Nck-CD3 epsilon association in vivo, we demonstrate that TCR-CD3 recruitment of Nck is critical for maturation of the immune synapse and for T cell activation."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00799-7"xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/author | "Alarcon B."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/author | "Gil D."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/author | "Schamel W.W."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/author | "Montoya M."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/pages | "901-912"xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/title | "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation."xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/12110186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12110186 |
| http://purl.uniprot.org/citations/12110186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12110186 |
| http://purl.uniprot.org/uniprot/P07766#attribution-3AB24008C92C1CDC084D7A35F54F862E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110186 |
| http://purl.uniprot.org/uniprot/P07766#attribution-9209EC0E4B18E3D16CD2B862FD7A2588 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110186 |
| http://purl.uniprot.org/uniprot/P07766#attribution-FE1C3E7C060C745C76E626C76C7BED55 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110186 |
| http://purl.uniprot.org/uniprot/O43639#attribution-3AB24008C92C1CDC084D7A35F54F862E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110186 |
| http://purl.uniprot.org/uniprot/O43639#attribution-FE1C3E7C060C745C76E626C76C7BED55 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110186 |
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