| http://purl.uniprot.org/citations/12123611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12123611 | http://www.w3.org/2000/01/rdf-schema#comment | "Activity-induced changes in adhesion molecules may coordinate presynaptic and postsynaptic plasticity. Here, we demonstrate that beta-catenin, which mediates interactions between cadherins and the actin cytoskeleton, moves from dendritic shafts into spines upon depolarization, increasing its association with cadherins. beta-catenin's redistribution was mimicked or prevented by a tyrosine kinase or phosphatase inhibitor, respectively. Point mutations of beta-catenin's tyrosine 654 altered the shaft/spine distribution: Y654F-beta-catenin-GFP (phosphorylation-prevented) was concentrated in spines, whereas Y654E-beta-catenin-GFP (phosphorylation-mimic) accumulated in dendritic shafts. In Y654F-expressing neurons, the PSD-95 or associated synapsin-I clusters were larger than those observed in either wild-type-beta-catenin or also Y654E-expressing neurons. Y654F-expressing neurons exhibited a higher minifrequency. Thus, neural activity induces beta-catenin's redistribution into spines, where it interacts with cadherin to influence synaptic size and strength."xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)00764-x"xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/author | "Mosser E."xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/author | "Murase S."xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/author | "Schuman E.M."xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/pages | "91-105"xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/title | "Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function."xsd:string |
| http://purl.uniprot.org/citations/12123611 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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