| http://purl.uniprot.org/citations/12135761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12135761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12135761 | http://www.w3.org/2000/01/rdf-schema#comment | "The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. We have identified PRG3 (p53-responsive gene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF, and the gene was assigned to chromosome 10q21.3-q22.1. Expression of PRG3 was induced by the activation of endogenous p53 and it contains a p53-responsive element. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. An amino-terminal deletion mutant of PRG3 that lacks a putative oxidoreductase activity retains its apoptotic activity, suggesting that the oxidoreductase activity is dispensable for the apoptotic function of PRG3. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)03049-1"xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)03049-1"xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Horikoshi N."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Horikoshi N."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Sreekumar K.R."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Sreekumar K.R."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Duffy S.L."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Duffy S.L."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Garkavtsev I."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Garkavtsev I."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Higashikubo B.T."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Higashikubo B.T."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Higashikubo R."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Higashikubo R."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Kley N."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Kley N."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Nantz R."xsd:string |
| http://purl.uniprot.org/citations/12135761 | http://purl.uniprot.org/core/author | "Nantz R."xsd:string |