| http://purl.uniprot.org/citations/12145154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145154 | http://www.w3.org/2000/01/rdf-schema#comment | "11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) converts inactive corticosteroids into biologically active corticosteroids, thereby regulating the local concentration of active glucocorticoids, such as cortisol. 11beta-HSD-1 is particularly expressed in adipocytes and liver and appears to be causally linked to the development of type 2 diabetes and the metabolic syndrome. Liver X receptor (LXR)-alpha and -beta are nuclear oxysterol receptors whose key role in lipid metabolic regulation has recently been established. In this study, we show that treatment of adipocytes derived from 3T3-L1 cells and mouse embryonic fibroblasts in vitro with synthetic or natural LXR agonists decreases mRNA expression of 11beta-HSD-1 by approximately 50%, paralleled by a significant decline in 11beta-HSD-1 enzyme activity. Downregulation of 11beta-HSD-1 mRNA by LXRs started after a lag period of 8 h and required ongoing protein synthesis. Moreover, long-term per os treatment with a synthetic LXR agonist downregulated 11beta-HSD-1 mRNA levels by approximately 50% in brown adipose tissue and liver of wild-type but not of LXRalpha(-/-)beta(-/-) mice and was paralleled by downregulation of hepatic PEPCK expression. In conclusion, LXR ligands could mediate beneficial metabolic effects in insulin resistance syndromes including type 2 diabetes by interfering with peripheral glucocorticoid activation."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.51.8.2426"xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/author | "Oppermann U."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/author | "Steffensen K.R."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/author | "Stulnig T.M."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/author | "Schuster G.U."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/pages | "2426-2433"xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/title | "Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity."xsd:string |
| http://purl.uniprot.org/citations/12145154 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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