| http://purl.uniprot.org/citations/12145337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12145337 | http://www.w3.org/2000/01/rdf-schema#comment | "The Na+/H+ exchanger regulatory factor (NHE-RF; also known as ezrin-radixin-moesin binding protein 50) is a primary response gene under estrogen receptor (ER) control that may provide a link between estrogen action and the regulation of cytoskeletal and cell-signaling pathways. These studies were undertaken to define the human NHE-RF genomic regions and regulatory sequences mediating its robust estrogen responsiveness. Screening of a human genomic library yielded NHE-RF clones comprising the full gene, including the 5'-regulatory region and first exon, which were found to contain a large number (13) of consensus half-estrogen response elements (EREs), but to lack palindromic full EREs. Transfection-transactivation assays with wild-type and mutant ERs and reporter gene constructs linked to progressive deletions, or containing mutations, of the 5'-flanking region including a portion of exon I, and electrophoretic mobility and competitive gel shift assays were performed. These demonstrated direct ER interaction with the multiple half-ERE sites and the importance of the one proximal half-ERE and the multiple upstream half-EREs for eliciting the robust transcription activation of the NHE-RF gene by the estrogen-ER complex. Our findings highlight a paradigm for gene regulation via numerous half-ERE sites that expands the range of modes by which DNA recognition sites mediate the actions of this nuclear receptor."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2001-0290"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2001-0290"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Katzenellenbogen B.S."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Katzenellenbogen B.S."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Ediger T.R."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Ediger T.R."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Park S.-E."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/author | "Park S.-E."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/pages | "1828-1839"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/pages | "1828-1839"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/title | "Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/title | "Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements."xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12145337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12145337 |
| http://purl.uniprot.org/citations/12145337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12145337 |
| http://purl.uniprot.org/citations/12145337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12145337 |
| http://purl.uniprot.org/citations/12145337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12145337 |