| http://purl.uniprot.org/citations/12147675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12147675 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-independent death mechanisms have been shown to execute apoptosis in many types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death after acute injury such as DNA damage, ischemia, and excitotoxicity. Here, we demonstrate that p53 can induce neuronal cell death via a caspase-mediated process activated by apoptotic activating factor-1 (Apaf1) and via a delayed onset caspase-independent mechanism. In contrast to wild-type cells, Apaf1-deficient neurons exhibit delayed DNA fragmentation and only peripheral chromatin condensation. More importantly, we demonstrate that apoptosis-inducing factor (AIF) is an important factor involved in the regulation of this caspase-independent neuronal cell death. Immunofluorescence studies demonstrate that AIF is released from the mitochondria by a mechanism distinct from that of cytochrome-c in neurons undergoing p53-mediated cell death. The Bcl-2 family regulates this release of AIF and subsequent caspase-independent cell death. In addition, we show that enforced expression of AIF can induce neuronal cell death in a Bax- and caspase-independent manner. Microinjection of neutralizing antibodies against AIF significantly decreased injury-induced neuronal cell death in Apaf1-deficient neurons, indicating its importance in caspase-independent apoptosis. Taken together, our results suggest that AIF may be an important therapeutic target for the treatment of neuronal injury."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200202130"xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Park D.S."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Cecconi F."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Yu S.W."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Slack R.S."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Callaghan S.M."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Cregan S.P."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "Fortin A."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/author | "MacLaurin J.G."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/pages | "507-517"xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/title | "Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/12147675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12147675 |
| http://purl.uniprot.org/citations/12147675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12147675 |
| http://purl.uniprot.org/uniprot/#_G3XA09-mappedCitation-12147675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12147675 |
| http://purl.uniprot.org/uniprot/#_O88879-mappedCitation-12147675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12147675 |
| http://purl.uniprot.org/uniprot/#_Q5DU30-mappedCitation-12147675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12147675 |
| http://purl.uniprot.org/uniprot/#_Q80VR5-mappedCitation-12147675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12147675 |