| http://purl.uniprot.org/citations/12154071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12154071 | http://www.w3.org/2000/01/rdf-schema#comment | "Farnesyl transferase inhibitors induce G2/M cell cycle delays that cannot be explained by inhibition of the Ras GTPase. Recently, the kinetochore protein Cenp-F has been shown to be farnesylated. Here, we show that ectopic expression of the kinetochore targeting domain of Cenp-F delays progression through G2/M. Significantly, this is dependent on the CAAX farnesylation motif. We also show that localisation of Cenp-F to the nuclear envelope at G2/M and kinetochores in prometaphase is dependent both on its CAAX motif and farnesyl transferase activity. Strikingly, farnesyl transferase activity is also required for Cenp-F degradation after mitosis. Thus, these observations suggest that farnesylation of Cenp-F is required not only for its localisation to the nuclear envelope and kinetochores but also for timely progression through G2/M and its degradation after mitosis. In addition, these observations raise the possibility that the anti-proliferative effects induced by farnesyl transferase inhibitors may be due to inhibition of Cenp-F function and/or turnover."xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115.17.3403"xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/author | "Hussein D."xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/pages | "3403-3414"xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/title | "Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis."xsd:string |
| http://purl.uniprot.org/citations/12154071 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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