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| http://purl.uniprot.org/citations/12154096 | http://www.w3.org/2000/01/rdf-schema#comment | "Ectopic expression of Wnt-1 in 3T3-L1 preadipocytes stabilizes beta-catenin, activates TCF-dependent gene transcription, and blocks adipogenesis. Here we report that upon serum withdrawal, Wnt-1 causes 3T3-L1 cells to resist apoptosis through a mechanism that is partially dependent on phosphatidylinositol 3-kinase. Although activation of Wnt signaling by inhibition of GSK-3 activity or ectopic expression of dominant stable beta-catenin blocks apoptosis, inhibition of Wnt signaling through expression of dominant negative TCF-4 increases apoptosis. Wnt-1 stimulates 3T3-L1 preadipocytes to secrete factors that increase PKB/Akt phosphorylation at levels comparable with treatment with 10% serum. With DNA microarrays, we identified several secreted antiapoptotic genes that are induced by Wnt-1, notably insulin-like growth factor I (IGF-I) and IGF-II. Consistent with IGFs mediating the antiapoptotic effects of Wnt-1 in preadipocytes, conditioned medium from Wnt-1 expressing 3T3-L1 cells was unable to promote protein kinase B phosphorylation after the addition of recombinant IGFBP-4. Thus, we demonstrated that Wnt-1 induces expression of antiapoptotic genes in 3T3-L1 preadipocytes such as IGF-I and IGF-II, which allows these cells to resist apoptosis in response to serum deprivation."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206402200"xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "MacDougald O.A."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "Ross S.E."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "Wright W.S."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "Longo K.A."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "Kennell J.A."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/author | "Ochocinska M.J."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/pages | "38239-38244"xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/title | "Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors."xsd:string |
| http://purl.uniprot.org/citations/12154096 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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